Bilirubin Interaction with Ganglioside: Possible Mechanism in Kernicterus
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چکیده
منابع مشابه
Unbound bilirubin: a better predictor of kernicterus?
The peroxidase method described in this paper measures non–protein-bound bilirubin by oxidation of the free fraction. The oxidation rate is slow compared with rapid dissociation of albumin-bound bilirubin. Thus, the unbound bilirubin can be estimated from the initial rate of decline in total bilirubin concentration. In the 1970s, severe neonatal hyperbilirubinemia and kernicterus were major cli...
متن کاملStudies in kernicterus. I. The protein binding of bilirubin.
The yellow staining of basal ganglia (kernicterus) in some jaundiced newborn infants has been recognized for many years (1). The association between serum bilirubin concentration and kernicterus (2, 3), the isolation of bilirubin from kernicteric brains (4, 5), and the toxic effect of bilirubin in vitro upon oxygen uptake (6) and oxidative phosphorylation (7) are further evidence of a relations...
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Cell-cell interaction is a basic topic in biological sciences. In embryogenesis, a largely unsolved problem is the means by which cell-cell recognition, necessary for the build up of a normal tissue, is mediated (1). Under pathological conditions this hitherto unrevealed mechanism of physiological interactions seems to be lost. In immunology numerous phenomena are based on cell-cell interaction...
متن کاملBinding of bilirubin with lipid. A possible mechanism of its toxic reactions in mitochondria.
Binding of bilirubin with mitochondria, mitochondrial membranes, various cells, and cellular fragments resulted in a hypochromicity with a red shift of the absorption spectrum of bilirubin. It was found that the mitochondrial lipids rather than the proteins were involved in the binding. Isolated mitochondrial lipid and lipids from various other sources caused similar spectral changes of the bil...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1975
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-197510000-00009